Detailed Product Description

The Chemtrue® One-Step Buprenorphine Test is a lateral flow, one-step immunoassay for the qualitative detection of Buprenorphine in human urine at a cut-off of 10ng/ml. This product is used to obtain a visual, qualitative result and is intended for professional use.

This assay provides only a preliminary analytical test result. A BUP e specific alternate chemical method must be used in order to obtain a confirmed analytical result. Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory method. Clinical consideration and professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are used.

Buprenorphine is a potent analgesic often used in the treatment of opioid addition. Therapeutically, Buprenorphine is used as a substitution treatment for opioid addicts. Substitution treatment is a form of medical care offered to opiate addicts (primarily heroin addicts) based on a similar or identical substance to the drug normally used. In substitution therapy, Buprenorphine is as effective as Methadone but demonstrates a lower level of physical dependence. Concentrations of free Buprenorphine and Norbuprenorphine in urine may be less than 1 ng/mL after therapeutic administration, but can range up to 20ng/mL in abuse situations. The plasma half-life of Buprenorphine is 2-4 hours. While complete elimination of a single-dose of the drug can take as long as 6 days, the detection window for the parent drug in urine is the thought to be approximately 3 days.

The Chemtrue® One-Step Buprenorphine Test is based on the principle of highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. This test is a rapid, visual, competitive immunoassay that can be used for the qualitative detection of Buprenorphine in human urine at a 10 ng/mL cut-off concentration.